Cryotherapy is a treatment to remove certain skin lesions by freezing their surface using cryogens like Liquid nitrogen (the most commonly used), Carbon dioxide snow, or Dimethyl ether and propane or DMEP.

Indications of Cryotherapy

  • Benign skin problems like actinic keratosis, solar lentigo, seborrheic keratosis, viral wart, molluscum contagiosum, and dermatofibroma
  • Lesions in most non–hair-bearing areas of the body
  • Occasionally basal cell carcinoma can be treated


The dose and delivery method of liquid nitrogen depends upon the size, location, and depth of the lesion. Liquid nitrogen spray method can be done by the following techniques:

  • Timed spot freeze or direct spray technique
  • Rotary or spiral pattern
  • Paintbrush method

Advantages of Cryotherapy

  • Requires little time
  • Low risk of infection
  • Minimal wound care
  • Short preparation time